The Paint, Clone, and Erase Brushes have a selection of dynamic properties: size , angle, roundness, opacity, and flow. These can only be used with a pressure-sensitive tablet like those from Wacom.
You can link these dynamics to pen pressure, pen tilt, or a stylus wheel. (Some tablet accessories such as Wacom's Intuos Airbrushes include a stylus wheel). Using Dynamics adds more professional functionality to the Paint Effect and you may want to get a tablet if you don't have one. Other than the ease of drawing with a pen you can vary the size, angle, roundness, opacity, and flow within the same paint stroke.