The majority of Photoshop users print their images on desktop printers most of the time. These printers generally fall into three categories:
RGB vs. CMYK
While inkjet printers use CMYK inks, they prefer to ingest RGB images. If the image is in RGB mode, there is no reason to convert if you're using an inkjet printer. Desktop printers are designed to do their own CMYK conversion using internal software. Sending a CMYK image to an inkjet printer will usually result in a second (and unpredictable) color conversion. It is important to realize that the computer screen can display more colors than the printer can print. You might want to use the Gamut Warning command (View > Gamut Warning) to identify areas that need to be toned down before printing.
Several specialty papers are available for desktop printers. You will not get good results trying to print on plain white copy paper. These specialty papers must be selected in the printer window. It's a good idea to identify the paper you are using so the print driver can adjust the density of the ink coverage to match the paper stock. To conserve paper, you might want to create and print a contact sheet or picture package with several smaller images first.