The best place to start is with a question. What do you want to know? What's not working the way you expect it to work? What QuickBooks features do you think should provide you with more value? What kind of information are you trying to get from your QuickBooks program? Ask the question and then go to the table of contents or the index to find the area of the book that contains the answer.
Chances are, you'll begin by finding the answer to your question, and then you'll start paging through the book, discovering new features and learning tips for making your QuickBooks experience more worthwhile and efficient.