| Syndrome | Clinical Features | Antibody | Typical Cancer | | Brainstem encephalitis | Ataxia, cranial n. or motor dysfunction, abnl CSF | Ma1, Ma2 | Small-cell lung cancer (SCLC), testicular | | Limbic encephalitis | Depression, confusion, abnl CSF | Hu, others | SCLC | | Subacute cerebellar degen. | Ataxia, dysarthria, nystagmus, nl CSF | Yo (AKA Purkinje cell) | Breast, ovary; SCLC | | Opsoclonus, myoclonus | Jerky eye and limb movement | Ri | Lung, breast | | Isolated CNS angiitis | | | Hodgkin's | | Retinal degeneration | Loss of vision | Retinal | SCLC, melanoma | | Spinal Cord Sx | | | | | Necrotizing myelopathy | Weakness, sensory loss | ? | SCLC | | Motor neuron disease | Weakness, fasciculations | ? | Various lymphomas and carcinomas | | Stiff person syndrome | Painful spasms | Amphiphysin, GAD | Lung, lymphoma, breast, thymoma | | Peripheral Nerve Sx | | | | | Subacute sensory neurop. | Sensory ataxia, gait instability, dysesthesias | Hu, others | SCLC, plasma cell dyscrasias | | Gammopathy-assoc. neurop. | Sensory loss, weakness, areflexia | Monoclonal Ig | Myeloma, Waldenstrom's, lymphoma | | Guillain-Barr (AIDP) | Rapid weakness, areflexia | ? | Lymphoma | | Neuromuscular Junction Sx | | | | | Lambert-Eaton | Proximal weakness, areflexia, eyes spared | Calcium channel | SCLC (1%-3% of pts.) | | Myasthenia gravis | Weakness, areflexia, eyes often involved | ACh receptor | Thymoma (15% of pts.) | | Muscle Sx | | | | | Dermato- or polymyositis | Weakness, high CPK | Muscle | Breast, lung, GI, uterine, ovarian, Hodgkin's | |
