While many databases are dedicated to organizing protein families and protein domains, Pfam is our preferred database for predicting the function of newly-discovered proteins. Pfam is unique in that it is a manually curated database of protein families derived from protein multiple sequence alignments and profile hidden Markow models. Pfam is a key database for understanding protein function and structure. It is used in many methods, including phylogenetic analysis, secondary structure prediction, and sequence annotation. We're using Pfam Release 7.8.