Adults and kids like trendy comedy. I say trendy comedy because comedy, by its nature, tends to be trendy. Many TV shows of the past that seemed hilarious, witty, or cutting-edge when new no longer seem quite as funny. These include I Love Lucy, Remington Steel, M*A*S*H, Cheers, Northern Exposure, and even Seinfeld. Comedy tends to date.
It's to the credit of the writers and other creative talent behind The Simpsons that they managed to keep it alive for so many years.
Grand Theft Auto III used a style of comedy popularized in such films as Pulp Fiction.
How can you predict the next trend in comedy? There's no formula. But one thing you can do is pay attention to the trends, and watch which trends seem to have the most staying power.