Are there any games that wouldn't require keyboard support?
A1:
Sure. Any game that requires extensive point-and-click style input, such as a card game, would probably be fine without any keyboard support. In fact, you create a memory game in Hour 8, "Example Game: Brainiac," that is perfectly suited for mouse input alone. However, if you can figure out a way to add keyboard controls to mouse-centric games, by all means go for it.
Q2:
Is it possible to mix keyboard and mouse controls?
A2:
Of course! This actually hits on an interesting point not directly covered in this hour: Many games work great by combining mouse and keyboard controls together. A good example is the strafing feature in Doom, which also works with the mouse; it is activated by holding down the Shift key while moving the mouse left or right.