The biggest challenge I face is getting people to think about what could be, as opposed to what is. People like to continuously fine-tune the way things are. Enacting change is one of the hardest things to do. Machiavelli pointed out that change is the hardest thing to bring about because people always have a vested interest in the way things are.
If you have an organization that is used to change and that embraces the concept of change, then you're going to make changes for good business decisions. You have to be an evangelist. You have to identify the problems, enumerate them, and then identify the vision to make it better. Businesses can evangelize about making more money by solving the customers' needs.