Diuretics

Authors: Flaherty, Alice W.; Rost, Natalia S.

Title: Massachusetts General Hospital Handbook of Neurology, The, 2nd Edition

Copyright 2007 Lippincott Williams & Wilkins

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Diuretics

A. Acetazolamide (Diamox)

A carbonic anhydrase inhibitor that raises extracellular carbon dioxide and decreases CSF formation. It is used in pseudotumor cerebri and sometimes as an adjunct ACD. SEs: rash, agranulocytosis, paresthesias. Follow CBC, electrolytes.

P.169

B. Furosemide (Lasix)

A loop diuretic. 10-40 mg IV bolus; 20-80 mg PO qd-bid. SEs: low BP, low K, ototoxicity.

C. Mannitol

Osmotic diuretic used to lower intracranial or intraocular pressure. 25% mannitol is 1,375 mOsm/L. Cleared renally in about 3 h, but ICP effect lasts 3-8 h. see p. 68.