In just over seven years, e-commerce database technology has become the common user interface of choice for many information dissemination systems. Whereas, relational database management systems (RDBMS) have been the cornerstone for information warehousing for years. The integration of the two technologies have made rapid advances over the last few years. This rapid explosion has led to new challenges for IT managers and developers. There are several competing technologies available that often do not address the issues of heterogeneous environments and Web-based application development. This chapter addresses the challenges of designing and implementing e-commerce database-integrated Web sites. Furthermore, it focuses on e-commerce database-Web integration difficulties in heterogeneous database environments.