Flylib.com

Books Software

 
 
 

Paraneoplastic Syndromes

Authors: Flaherty, Alice W.; Rost, Natalia S.

Title: Massachusetts General Hospital Handbook of Neurology, The, 2nd Edition

> Table of Contents > Adult Neurology > Paraneoplastic Syndromes

Paraneoplastic Syndromes

A. Incidence

Although rare (1% of cancer pts.), paraneoplastic syndromes precede the diagnosis of cancer in about 60% of cases.

Table 22. Paraneoplastic syndromes .

Syndrome Clinical Features Antibody Typical Cancer
Brainstem encephalitis Ataxia, cranial n. or motor dysfunction, abnl CSF Ma1, Ma2 Small- cell lung cancer (SCLC), testicular
Limbic encephalitis Depression, confusion, abnl CSF Hu, others SCLC
Subacute cerebellar degen. Ataxia, dysarthria, nystagmus, nl CSF Yo (AKA Purkinje cell) Breast , ovary; SCLC
Opsoclonus, myoclonus Jerky eye and limb movement Ri Lung, breast
Isolated CNS angiitis     Hodgkin's
Retinal degeneration Loss of vision Retinal SCLC, melanoma
Spinal Cord Sx      
Necrotizing myelopathy Weakness, sensory loss ? SCLC
Motor neuron disease Weakness, fasciculations ? Various lymphomas and carcinomas
Stiff person syndrome Painful spasms Amphiphysin, GAD Lung, lymphoma, breast, thymoma
Peripheral Nerve Sx      
Subacute sensory neurop. Sensory ataxia, gait instability, dysesthesias Hu, others SCLC, plasma cell dyscrasias
Gammopathy-assoc. neurop. Sensory loss, weakness, areflexia Monoclonal Ig Myeloma, Waldenstrom's, lymphoma
Guillain-Barr (AIDP) Rapid weakness, areflexia ? Lymphoma
Neuromuscular Junction Sx      
Lambert-Eaton Proximal weakness, areflexia, eyes spared Calcium channel SCLC (1%-3% of pts.)
Myasthenia gravis Weakness, areflexia, eyes often involved ACh receptor Thymoma (15% of pts.)
Muscle Sx      
Dermato- or polymyositis Weakness, high CPK Muscle Breast, lung, GI, uterine, ovarian, Hodgkin's

Authors: Flaherty, Alice W.; Rost, Natalia S.

Title: Massachusetts General Hospital Handbook of Neurology, The, 2nd Edition

> Table of Contents > Adult Neurology > Peripheral Nerve Anatomy

Peripheral Nerve Anatomy

A. See also

Peripheral Neuropathy p. 93 .

B. Spinal level by disc

Table 23. Symptoms of disc herniation .

Disc Root Motor Sensory Reflex
C5-6 C6 Biceps, wrist ext. Med. arm and hand Biceps
C6-7 * C7 Triceps, wrist flex. Middle finger Triceps
C7-T1 C8 Finger flex. Lat. hand Finger
L3-4 L4 Quadriceps Med. calf Knee
L4-5 * L5 Dorsiflexors Med. foot  
L5-S1 S1 Plantar flexors Lat. foot Ankle
* Most common syndromes.

Figure 10 . Dermatomes and peripheral nerve territories . (From Patton HD, et al. Introduction to Basic Neurology . Philadelphia: Saunders; 1976, with permission.)

P.90


C. Spinal level by function

  • 1. Movement :

    • a. Neck : C1-4.

    • b. Diaphragm : C3-5.

    • c. Shoulder : Abduction and lateral rotation are C5. Adduction and medial rotation are C6-8.

    • d. Elbow : Flexion is C5-6. Extension is C6-8.

    • e. Wrist : C6-8. Extension = radial n. Flexion = median + ulnar n.

    • f. Hand : Finger abduction and adduction are ulnar nerve (C8-T1). Grip is median nerve. Finger extension is radial nerve.

    • g. Thumb test : Can tell radial, median, and ulnar nerve lesions by thumb movements. Mnemonic is RUM : R adial extends, U lnar adducts, and M edian abducts. Flexion + extension = in plane of the palm; abduction + adduction = at right angles to the palm.

    • h. Intercostals : T2-9.

    • i. Abdominals : Upper is T9-10. Lower is T11-12.

    • j. Hip : Flexion is L2-4, adduction is L3-4, abduction is L5-S1.

    • k. Knee : Extension is L2-4; flexion is L4-S1.

    • l. Foot : Dorsiflexion is L4-S1; plantar flexion is S1-2.

    • m. Bladder, anal sphincter : S2-4.

  • 2. Sensation :

    • a. Arm : Shoulders: C4; inner forearm: C6; outer forearm: T1; thumb: C6; fifth finger: C8.

    • b. Leg : Front of thigh: L2; medial calf: L4; lateral calf: L5; fifth toe: S1; midline buttocks: S3.

D. Spinal level by nerve

  • 1. See also : p. 95 for sx of common entrapment syndromes.

    Figure 11 . The brachial plexus. (From Warwick R, Williams P. Gray's Anatomy . 35th ed. London: Churchill Livingstone; 1973, with permission.)

  • P.91


  • 2. Brachial plexus : C5-T1.

    • a. Plexi :

      • 1) Upper plexus : C5-6. Deltoids, biceps, supra- + infraspinatus.

      • 2) Middle plexus : C7.

      • 3) Lower plexus : C8-T1.

    • b. Cords : Upper-mid-lower plexi recombine to form three cords; lateral and medial cord then recombine to form median nerve.

      • 1) Lateral cord (from upper + middle plexus) forms musculocutaneous nerve, lateral anterior thoracic nerve, median nerve.

      • 2) Posterior cord (from upper, middle, and lower plexus) forms radial nerve, axillary nerve, and subscapular nerve.

      • 3) Medial cord (from lower plexus) forms ulnar nerve, medial cutaneous nerve, median nerve.

  • 3. Nerves of arm : Note that any weakness of both flexors and extensors or of all intrinsic hand muscles implies that the lesion cannot be a mononeuropathy.

    • a. Long thoracic nerve : C5-7. Serratus anterior. Test: scapula wings when pt presses arm forward against a wall.

    • b. Axillary nerve : C5 -6. Deltoid, etc. Test: abduct arm >90 degrees.

    • c. Musculocutaneous nerve : C5 -6. Biceps.

    • d. Radial nerve : C5-8, esp. C7 . Extensors (triceps, wrist, and finger), supinator, brachioradialis.

    • e. Median nerve : C6-T1. Flexors except ulnar: most forearm flexors, flex. dig. superior ; all pronators. Hand: LOAF muscles ( L umbricals 1 and 2, O pp. pollicis, A bd. poll. brev., F lex. poll. brev.).

    • f. Ulnar nerve : C8-T1. Flexor digitorum profundus 3 and 4, flexor carpi ulnaris. Most of intrinsic hand (except LOAF muscles above): thumb adductors and flexors, interossei, lumbricals 3 and 4, hypothenar muscles.

  • 4. Leg :

    • a. Femoral nerve : L2-4.

      • 1) Function : Extend knee.

      • 2) Muscles : Iliopsoas, quadriceps, sartorius, rectus femoris.

    • b. Obturator nerve : L2-4.

      • 1) Function : Adduct leg.

      • 2) Muscles : Adductor longus, brevis, and magnus; gracilis, pectineus .

    • c. Sciatic nerve (tibial and peroneal nerve): L4-S2.

      • 1) Function : Extend and abduct hip, flex knee, all foot mvts.

        • a) Deep peroneal nerve : Extends toes and ankle.

        • b) Superficial peroneal nerve : Everts foot.

        • c) Tibial nerve : Superficial tibial flexes foot; deep tibial flexes toes.

      • 2) Muscles : Semitendinosus and semimembranosus, biceps femoris, gastrocnemius, soleus, foot muscles .

E. Spinal level by reflex

  • 1. Cervical : Biceps is C5-6. Supinator is C5-6. Triceps is C6-8.

  • 2. Thoracic : Scratch towards navel. Contraction with scratching above navel is T8-10; below navel is T10-12.

  • 3. Lumbar : Knee is L2-4. Ankle is S1-2. Babinski is L4-S2.